On the use of boronates in the Petasis reaction

Autor:	Géraldine Gouhier, Patrick Rene Angibaud, Helene Jourdan, Luc Van Hijfte, Serge R. Piettre
Rok vydání:	2005
Předmět:	chemistry.chemical_compound Primary (chemistry) Petasis reaction Chemistry Scientific method Organic Chemistry Drug Discovery Hexafluoropropanol Organic chemistry Methanol Biochemistry
Zdroj:	Tetrahedron Letters. 46:8027-8031
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2005.09.060
Popis:	Alcohols are solvents of choice to react boronates, aldehydes and either primary or secondary amines. Thus, while the reaction proceeds sluggishly, or not at all, in aprotic solvents, the desired aminoacids are in most cases obtained in high yields when conducted in methanol or hexafluoro-iso-propanol. In the case of secondary amines, microwave activation is shown to strongly accelerate the process without altering the yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d939f5de5f502978029a20b099d93796 https://doi.org/10.1016/j.tetlet.2005.09.060 Zobrazit plný text záznamu Full Text from ScienceDirect