Boronic Acid Decorated Defective Metal-Organic Framework Nanoreactors for High-Efficiency Carbohydrates Separation and Labeling
| Autor: | Xu'an Fang, Zhen-Song Zhong, Fang Zhu, Guosheng Chen, Qing Chen, Gangfeng Ouyang, Jin'ge Zhang, Jianqiao Xu |
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| Rok vydání: | 2017 |
| Předmět: |
Glycobiology
Reaction speed One-Step 02 engineering and technology Nanoreactor 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences Electronic Optical and Magnetic Materials Biomaterials Glycomics chemistry.chemical_compound chemistry Electrochemistry Organic chemistry Metal-organic framework 0210 nano-technology Boronic acid |
| Zdroj: | Advanced Functional Materials. 27:1702126 |
| ISSN: | 1616-301X |
| DOI: | 10.1002/adfm.201702126 |
| Popis: | Separation and labeling are the crucial steps for the carbohydrates identification and detection in the important field of biochemistry, biomedicine, glycomics, and glycobiology. Herein, for the first time, a boronic acid decorated defective metal–organic framework (B-D-MI-100) nanoreactor is designed, which integrates fast separation and labeling of carbohydrates into one step. Without the sacrifice of internal room space, the incorporation of abundant functional boronic acid groups into the framework is achieved through metal–ligand–fragment coassembly strategy. And the novel solid phase orientation labeling approach performed within elaborate Cr based B-D-MIL-100 nanoreactor is facile to avoid the conformation transition of carbohydrates occurred in classical liquid-phase labeling. As a result, the novel approach presents several merits, including high separation efficiency (almost all of the incorporated boronic acid groups are available), much fast labeling reaction speed (labeling reaction time is decreased from 7 h to 3 min), high purity of the product, and three orders of magnitude lower applicable carbohydrate concentration for labeling. Thus, this new approach advances the idea to efficiently detect and identify trace carbohydrates in important fields such as glycomics and glycobiology. |
| Databáze: | OpenAIRE |
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