False resistance to imipenem with a microdilution susceptibility testing system

Autor:	Ann B. Macone, Donald A. Goldmann, K C Parsonnet, Kathleen G. Lambert, Edward J. O'Rourke
Rok vydání:	1991
Předmět:	Microbiology (medical) Imipenem medicine.medical_specialty Susceptibility testing Pseudomonas aeruginosa Biology medicine.disease_cause Microbiology Antibiotic resistance Internal medicine medicine Potency medicine.drug Antibacterial agent
Zdroj:	Journal of Clinical Microbiology. 29:827-829
ISSN:	1098-660X 0095-1137
DOI:	10.1128/jcm.29.4.827-829.1991
Popis:	Routine monitoring of antibiotic resistance at Children's Hospital, Boston, detected a dramatic increase in the prevalence of imipenem-resistant strains of Pseudomonas aeruginosa. Further studies documented that false resistance to imipenem was due, in part, to the loss of imipenem potency in customized MIC microdilution trays supplied by Sensititre Ltd. (West Sussex, United Kingdom). Recognition of the problem was delayed by use of the quality control standard recommended by the manufacturer, which were higher and broader than those suggested by the National Committee for Clinical Laboratory Standards.
Databáze:	OpenAIRE
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