B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity
| Autor: | Thomas Prod'homme, Juan C. Patarroyo, Nicolas Molnarfi, Tara Karnezis, Scott S. Zamvil, Anthony J. Slavin, Christopher Linington, Claude C.A. Bernard, Klaus Lehmann-Horn, Jeffrey Eastham-Anderson, Flavius Martin, Martin S. Weber, Dimitry M. Danilenko |
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| Rok vydání: | 2010 |
| Předmět: |
biology
Multiple sclerosis Encephalomyelitis Experimental autoimmune encephalomyelitis Central nervous system medicine.disease medicine.disease_cause Myelin oligodendrocyte glycoprotein Autoimmunity medicine.anatomical_structure Neurology Antigen immune system diseases Immunology biology.protein medicine Neurology (clinical) Antibody |
| Zdroj: | Annals of Neurology. 68:369-383 |
| ISSN: | 0364-5134 |
| Popis: | Objective Clinical studies indicate that anti-CD20 B cell depletion may be an effective multiple sclerosis therapy. We investigated mechanisms of its immune modulation using two paradigms of experimental autoimmune encephalomyelitis (EAE). |
| Databáze: | OpenAIRE |
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