SEROLOGICAL AND MOLECULAR MARKERS OF HERPESVIRUS INFECTIONS IN THE DEBUT OF ANGIOIMMUNNOBLASTIC T-CELL LYMPHOMA

Autor:	S. M Kulikov, Yu. V. Sidorova, Tikhomirov Ds, Filatov Fp, N. G Yaroslavtseva, E E Zvonkov, N G Chernova, T.A. Tupoleva, M N Sinitsyna
Rok vydání:	2018
Předmět:	business.industry hemic and lymphatic diseases Medicine T-cell lymphoma business medicine.disease Virology Serology
Zdroj:	Epidemiology and Infectious Diseases. 23:77-84
ISSN:	2411-3026 1560-9529
DOI:	10.18821/1560-9529-2018-23-2-77-84
Popis:	Background. Angioimmunoblastic T-cell lymphoma (AITL) is the rare lymphoproliferative disorder traditionally thought to be associated with EBV. This original study gives data about serological and molecular markers of herpes viruses in primary AITL patients. Materials and methods. The review includes analysis of clinical and laboratory features of 40 primary AITL patients. Peripheral blood, lymph node, bone marrow and bronco-alveolar aspirate samples were tested by ELISA, PCR and in situ hybridization. Results. Laboratory markers of the acute herpetic infection were detected in 29 (72.0%) out of 40 patients. Primary infection was detected in 8 cases: 6 - primary EBV, 1 - HCMV and 1-EBV and HCMV simultaneously. Anti-HSV 1,2 IgM were observed in 15 (37.5%) patients. EBV small non-coding RNAs (EBER) was positive in 27 (71.1%) out of 38 cases. The comparison of the detection of EBER and markers of acute EBV infection showed good correlation (p
Databáze:	OpenAIRE
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