Antitumor effects of the electromagnetic resonant frequencies derived from the 1H NMR spectrum of Ph3Sn(Mercaptonicotinic)SnPh3 complex
| Autor: | Nikolaos Papadopoulos, Angelos M. Evangelou, Evangelia Dounousi, Ioannis I. Verginadis, Yannis V. Simos, Vasilios Ragos, Antonis Avdikos, Anastasia Velalopoulou, Spyridon Ch. Karkabounas, Dimitrios Peschos, Ioannis Zelovitis |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Leiomyosarcoma Programmed cell death Chemistry Biological activity General Medicine medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine In vivo Apoptosis medicine Biophysics Proton NMR Cytotoxic T cell Viability assay 030217 neurology & neurosurgery |
| Zdroj: | Medical Hypotheses. 133:109393 |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2019.109393 |
| Popis: | The aim of this article is to investigate the potential cytotoxic and antitumor effects of the resonant electromagnetic fields (rEMFs) derived from the 1H NMR spectrum of the Ph3Sn(Mercaptonicotinic)SnPh3 complex (SnMNA). The ability of the complex’s rEMFs to induce leiomyosarcoma (LMS) cell death and to recess tumor (leiomyosarcoma) development in Wistar rats was evaluated. The effects of the simultaneous administration of the SnMNA complex at extremely low concentrations and exposure to its rEMFs was also investigated. The emission of the 1H NMR spectrum of the complex alone or in a combination with low ineffective doses of the complex decreased LMS cell viability mainly through apoptosis. Moreover, the results from the in vivo experiments showed a significant prolongation of life expectancy in tumor-bearing rats exposed to the rEMFs alongside a deceleration in tumor growth rate. We speculate that the rEMFs of a biologically active substance could exert similar biological effects as the substance itself, mainly when is combined with extremely low ineffective concentrations of the substance. |
| Databáze: | OpenAIRE |
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