BDNFMet allele Is Associated With Lower Cognitive Function in Poststroke Rehabilitation
| Autor: | Mingzhu Xu, Qinfeng Xu, Jiening Wang, Xun Luo, Yapeng Li, Qing Mei Wang, Lei Cai, Zhenxiang Han, John B. Wong, Xinjia Hu, Yuling Zhang, Lili Qi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Brain-derived neurotrophic factor
medicine.medical_specialty Rehabilitation business.industry medicine.medical_treatment Cognition General Medicine Odds ratio 030204 cardiovascular system & hematology Functional Independence Measure 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype Medicine Allele business Allele frequency 030217 neurology & neurosurgery |
| Zdroj: | Neurorehabilitation and Neural Repair. 34:247-259 |
| ISSN: | 1552-6844 1545-9683 |
| Popis: | Background and purpose. The identification of a genetic role for cognitive outcome could influence the design of individualized treatment in poststroke rehabilitation. The aim of this study is to determine whether brain-derived neurotrophic factor ( BDNF) Val66Met polymorphism is independently associated with poststroke functional outcome. Methods. A total of 775 stroke patients with genomic data were identified from the Partners HealthCare Biobank, which contains a large number of genotypes from Biobank’s consented patients. Of 775 stroke patients who met the inclusion/exclusion criteria, 86 were enrolled. Functional outcomes were assessed using the Functional Independence Measure scores at the time of admission and discharge. Logistic and linear regression models adjusted for covariate variables, including age, sex, and medical conditions, were used to evaluate the association between BDNF Val66Met and functional outcome. Results. We detected a significant correlation between Met alleles and lower cognitive function at discharge in both ischemic and hemorrhagic stroke patients. Genotyping findings confirmed that BDNF Met allele frequency was higher in contrast to Val/Val allele frequency in lower cognitive functional recovery. Furthermore, after adjusting for covariate variables, BDNF Met alleles were found to be associated with lower cognitive outcome [ P = .003; odds ratio (OR) = 5.95 (1.81-19.52)] and recovery [ P = .006; OR = 3.16 (1.4-7.15)], especially with lower problem solving, expression, and social recovery in all stroke patients. Conclusions. Met allele carriers exhibited impaired poststroke cognitive function. The BDNF genotype may be a useful predictor of cognitive function in inpatient poststroke rehabilitation. |
| Databáze: | OpenAIRE |
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