Autor:	Günther Jung, Thomas Redemann, Holger Bandel
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Peptidomimetic Stereochemistry Organic Chemistry Synthon Sequence (biology) Peptide General Medicine Polymer Catalysis Inorganic Chemistry chemistry Drug Discovery Physical and Theoretical Chemistry Molecular Biology Linker Information Systems
Zdroj:	Molecular Diversity. 4:191-197
ISSN:	1381-1991
DOI:	10.1023/a:1009698909575
Popis:	Boc-resin-bound α-hydroxy-β-amino-aldehydes are accessible starting from N-terminally bound amino acidesters by using Dondoni's C1-homologationreaction sequence. The conversion of these synthons totwo different peptide mimetics – 2-hydroxy-1,3-ethyl-diamines and γ-hydroxy-δ-amino-vinyl sulfones – hasbeen investigated. The successful transfer of thecomplex α-amino acid homologation reactionsequence into solid-phase chemistry demonstrates thepotentials of the Boc-resin for synthesis of peptidomimetics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d8f45fa84774c4907ab9e276d388fe86 https://doi.org/10.1023/a:1009698909575 Zobrazit plný text záznamu Full text from SpringerLink