| Autor: | Karine Anselme, Pierre Hardouin, B. Flautre, Christophe Delecourt, M. Descamps, Jianxi Lu |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
0303 health sciences
Stromal cell Materials science Mesenchymal stem cell Biomedical Engineering Biophysics Bioengineering 02 engineering and technology 021001 nanoscience & nanotechnology Autologous bone Bone tissue Biomaterials 03 medical and health sciences medicine.anatomical_structure medicine Bone marrow Stem cell 0210 nano-technology Bone regeneration Porosity 030304 developmental biology Biomedical engineering |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 10:811-814 |
| ISSN: | 0957-4530 |
| DOI: | 10.1023/a:1008923625599 |
| Popis: | The osteogenic potential of an association of two kinds of hydroxyapatite (HA) porous ceramics with autologous bone marrow cells cultured with or without dexamethasone (10-8M) addition in the culture medium and non-cultured rabbit marrow stromal stem cells (MSCs) was tested after 4 weeks of implantation in the dorsal muscles of spine in rabbit. A significantly higher number of rabbits with implants containing bone tissue inside pores were obtained with 107 cells ml-1 cultured treated with Dex. In the HA porous ceramic using naphtalen as porogen agent, the bone recolonization remains only at the periphery of implants and in the second row of pores, while in the HA porous ceramic using polymethacrylate (PMMA) microbeads as porogen agent, the bone recolonization is observed in the depth of implants. In the PMMA HA group, the Kru¨skal–Wallis variance analysis between the rabbits is significantly different with the percentage of number of occupied pores and occupied pores with bone tissue is different (p < 0.05). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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