Dynamic kinetic resolution of cyclic β-ketoesters with preformed or prepared in situ chiral diphosphine-ruthenium (II) catalysts
| Autor: | Jean Pierre Genêt, X. Pfister, Catherine Pinel, Virginie Ratovelomanana-Vidal, Jean-Alex Laffitte |
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| Rok vydání: | 1994 |
| Předmět: |
inorganic chemicals
Bicyclic molecule Chemistry organic chemicals Organic Chemistry Asymmetric hydrogenation Enantioselective synthesis chemistry.chemical_element Biochemistry Catalysis Ruthenium Kinetic resolution chemistry.chemical_compound Drug Discovery Tetralone Organic chemistry heterocyclic compounds Selectivity |
| Zdroj: | Tetrahedron Letters. 35:4559-4562 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/s0040-4039(00)60727-x |
| Popis: | The reduction of racemic β-keto esters having the tetralone structure by chiral ruthenium(II) catalysts is realized with an ideal kinetic dynamic resolution. Remarkably, high anti selectivity approaching 100% and enantioselectivity (up to 97%) using atropisomeric ligands are obtained. The trans β-hydroxy esters thus available are useful starting materials for production of enantiomerically pure compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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