A Zn azelate MOF: combining antibacterial effect
| Autor: | Patricia Horcajada, Nathalie Guillou, Erik Elkaim, Stuart R. Miller, C. Tamames-Tabar, María J. Blanco-Prieto, Christian Serre, Edurne Imbuluzqueta |
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| Rok vydání: | 2015 |
| Předmět: |
Thermogravimetric analysis
Minimum bactericidal concentration Azelaic acid biology Chemistry Infrared spectroscopy Nanotechnology General Chemistry Condensed Matter Physics Antimicrobial medicine.disease_cause biology.organism_classification Minimum inhibitory concentration Staphylococcus aureus Staphylococcus epidermidis medicine General Materials Science medicine.drug Nuclear chemistry |
| Zdroj: | CrystEngComm. 17:456-462 |
| ISSN: | 1466-8033 |
| Popis: | A novel biocompatible and bioactive Metal–Organic Framework (BioMOF), named BioMIL-5 (Bioactive Materials from Institut Lavoisier), was hydrothermally synthesized from a Zn2+ salt and azelaic acid, both with interesting antibacterial and dermatological properties. Its structure was determined by high resolution X-ray powder diffraction, and further characterized by infrared spectroscopy, thermogravimetric analysis and elemental analysis. The determination of the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values of BioMIL-5 in Staphylococcus aureus and Staphylococcus epidermidis demonstrated that the antimicrobial activity of the individual components of BioMIL-5 were maintained after its synthesis. Moreover, BioMIL-5 was found to be stable in water and in bacterial culture medium, especially in water, leading to the subsequent progressive release of its active constituents, AzA and Zn2+ ions. Interestingly, this slow active delivery allowed control of the growth of a S. epidermidis suspension over 7 days. The high stability of this material and the maintenance of its antibacterial properties make BioMIL-5 a good candidate for future bioapplications, for skin care and in cosmetics. |
| Databáze: | OpenAIRE |
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