Annual change of LCI among patients with cystic fibrosis
| Autor: | Elpis Hatziagorou, Lemonia Noursia, Vasiliki Avramidou, John Tsanakas, Fotis Kirvassilis, Dafni Papanikolaou, Despoina Terzi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Spirometry
medicine.medical_specialty medicine.diagnostic_test business.industry Mean age Lung Clearance Index medicine.disease Annual change Cystic fibrosis Surgery 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Disease severity Internal medicine medicine 030212 general & internal medicine Prospective cohort study business MULTIPLE BREATH WASHOUT |
| Zdroj: | 7.3 Cystic Fibrosis. |
| DOI: | 10.1183/13993003.congress-2016.oa1488 |
| Popis: | Introduction: Spirometry has been recognized as the gold standard method in monitoring patients with CF. Recently, there has been increasing interest on the significance of Lung Clearance Index (LCI) in monitoring patients with CF. There are no data on the annual % change of LCI, among patients with CF. Aim: To determine the annual % change of LCI among patients with CF; to detect if age, disease severity and chronic pseudomonas aeruginosa colonization have an impact on LCI. Method : In a 5-year prospective study, 80 stable CF patients performed 650 Multiple Breath Washout (MBW) measurements. Sixty-one patients who performed 578 measurements fulfilled the study criteria. Mean LCI of the first year was defined as LCI start and the mean LCI of the last year was defined as LCI end . The annual change in LCI (ΔLCI) and the annual % change of LCI were calculated. Results: Sixty-one patients with CF (31 males) with a mean age 9.64 years, mean FEV1% 100.4 and mean LCI start 9.03 participated in the study. The mean (sd) annual ΔLCI was 4.96% (4.16) and the mean (sd) ΔFEV 1 was 0.01% (3.41). Mean LCI start was correlated with age (p start and mean FEV 1start differed significantly between patients with different age (p start and FEV1 start . The mean LCI start was the only predictor of the mean annual ΔFEV1% (p>0.001, r 2 :0.281) Conclusion : The annual % change of LCI is 5% and it seems to be stable and independent of age, PsA and baseline lung function. |
| Databáze: | OpenAIRE |
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