| Popis: |
A Schiff base ligand [(E)-4-(((5-ethyl-1,3,4-thiadiazol-2-yl)imino)methyl)benzene-1,2,3-triol] (ETIMB) has been synthesized by condensation of an equimolar mixture of 5-Ethyl-1,3,4-thiadiazole-2-amino (0.01 mole) and 2,3,4-Trihydroxybenzaldehyde (0.01 mole) in absolute ethanol (25 ml). The ligand (ETIMB) was reacted with Ag(I), Ni(II), Cu(II) in ratio 1:1, 2:1, 2:1 respectively. The mixture was refluxed for 24 hrs. The Schiff base and its complexes were characterized by elemental (CHN) analysis, FTIR, electronic spectra,1HNMR spectra and Mass spectra. All complexes were screened for their in vitro anticancer potential using HeLa and PC3 cells. Cu(II) complex showed excellent cytotoxic activity towards HeLa cells. |
