Facile One-Pot Synthesis of PABA from MFB

Autor:	Kyung-Duck Kim, Young Ryu, Seok-Chan Kim
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Chemistry General Chemical Engineering One-pot synthesis chemistry.chemical_element General Chemistry Chloride Aldehyde chemistry.chemical_compound Ammonia Amide medicine Chlorine Organic chemistry Amine gas treating medicine.drug Benzoic acid
Zdroj:	Applied Chemistry for Engineering. 25:337-339
ISSN:	1225-0112
Popis:	A facile one-pot synthesis of p-aminobenzoic acid from methyl 4-formylbenzoate which is a main by product in dimethyl ter- ephthalate production process has been developed. This process involves the formation of amide intermediate obtained from the reaction of an aldehyde in methyl 4-formylbenzoate with chlorine in methylene chloride and the subsequent treatment of acid chloride with ammonia. The resulting amide was converted into amine using Hofmann degradation to afford a p-amino- benzoic acid. This facile one-pot process does not involve any expensive materials and should offer an attractive alternative to p-aminobenzoic acid production.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d8ca2052266a1ccb80eb31d741200f40 https://doi.org/10.14478/ace.2014.1020 Zobrazit plný text záznamu