ROLE OF VERAPAMIL (CALCIUM CHANNEL BLOCKER) AND LISINOPRIL (ANGIOTENSIN CONVERTING ENZYME INHIBITOR) ON MYOCARDIAL TOLERANCE TO ACUTE ISCHAEMIA
| Autor: | Ahmed El Gendy, Hanaa El Serougy, Sabry Gad, Soheir F. El Bassiony, Gad Abd Aziz |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
biology
business.industry medicine.drug_class Glucose uptake Lisinopril Angiotensin-converting enzyme Calcium channel blocker Pharmacology medicine.disease Contractility Heart rate biology.protein medicine General Earth and Planetary Sciences Verapamil business Reperfusion injury circulatory and respiratory physiology General Environmental Science medicine.drug |
| Zdroj: | Mansoura Medical Journal. 35:121-145 |
| ISSN: | 2735-3990 |
| DOI: | 10.21608/mjmu.2006.128721 |
| Popis: | This work aims to clarify the role of calcium channel blocker (verapamil) and angiotensin-converting enzyme inhibitor (lisinopril) on myocardial is-chaemia reperfusion injury. The study was done using isolated rabbits hearts and Langendroffs apparatus for recording myocardial contractility, heart rate and coronary flow, also glucose uptake by coronary slices was estimated by glucose enzymatic kit. The work included 4 groups; Group A to study effect of ischaemia and reperfusion on mentioned parameters, Group B to study effect of verapamil and lisinopril on tested parameters, Group C to study the effect of 5 minutes preischaemia administration of verapamil and lisinopril on tested parameters and Group D to study the effects of administration of verapamil and lisinopril with reperfusion on parameters mentioned before. Results concluded that global ischaemia decreased the myocardial contractility and heart rate but increases glucose uptake, verapamil is a potent drug used to decrease myocardial contractility, heart rate and increase coronary flow in ischaemic hearts. Lisinopril is a drug of choice to improve contractility and heart rate when administered preischaemic or with reperfusion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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