| Autor: |
Ferenc Perner, J. G. Szelenyi, G. Gy Petrányi, Rudolf Mihalik, I. Szigetvari, Anatolij Horuzsko, B. Schmidt, M. Réti, Eva Pocsik, M. Kassai, Ágnes Padányi, Éva Gyódi |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
Progress in Immunology Vol. VIII ISBN: 9783642514814 |
| DOI: |
10.1007/978-3-642-51479-1_103 |
| Popis: |
A special type of tolerance or suppressive regulation will be reported, which can be characterized by the complementary participation of two alloantigen systems; the major histocompatibility complex, and either a minor histocompatibility or certain type of differentiation antigen (secondary, subordinated) alloantigen system of functional importance. There are representative experimental observations on this phenomena, from which one characteristic model, reported by Hutchinson and Morris (Hutchinson and Morris 1987) is explained. Prior to kidney transplantation between RTL incompatible rats recipients were transfused with blood obtained from various strains characterized by either matching or mismatching with the transfusion and organ donor or recipient strain in the minor histocompatibility system. The matching between transfusion and kidney donor and a mismatching between transfusion donor and organ recipient as regards minor histocompatibility alloantigen system has to be emphasized as a new requirement. No similar situation has been reported in human beings. However, the induction of tolerance by transfusion in certain models is a well established phenomena. The importance of class II antigen matching between transfusion donor and recipient were outlined and proved in series of clinical observations based on in vivo and in vitro parameters including cytotoxic antibody production, MLC, cytotoxic precursor cell function and kidney survival (Lagaay et al. 1989, Claas et al 1991, van Rood and Claas 1990, de Waal and van Twuyer 1991). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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