Poor Tuberculosis Treatment Outcomes Associated with Older Age, Previous Treatment, HIV and Drug Resistance at Seven Hospitals in Indonesia
| Autor: | Muhammad Karyana, Armaji Kamaludi Syarief, Agus Dwi Harso, Aris Yulianto, Retna Mustika Indah, Dona Arlinda |
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| Rok vydání: | 2020 |
| Zdroj: | Jurnal Penelitian dan Pengembangan Pelayanan Kesehatan. :61-68 |
| ISSN: | 2599-1388 2598-8573 |
| DOI: | 10.22435/jpppk.v4i2.3698 |
| Popis: | Indonesia is a high burden country for tuberculosis (TB), multidrug-resistant (MDR) TB, and TB-HIV. We aimed to determine factors associated with poor TB treatment outcomes. A hospital-based TB Registry at seven referral hospitals in Java and Bali included data from patients aged ≥15 years who were diagnosed with TB from 1 January 2014 - 31 December 2015. The factors were assessed by logistic regression. From 2,051 TB patients, 1,180 (57.5%) were male and median age was 38 years (IQR 27-50 years), 452 (22%) had previous TB treatment history, 1,447 (70.6%) had pulmonary TB, 216 (10.5%) TB-HIV, 296 (14.4%) TB-DM and 248 (12.1%) were resistant to ≥1 anti-TB drug. Treatment outcome was unknown for 135 (6.6%) subjects and 1,137 (55.4%) who were still on treatment. Among the 779 with available outcome, 358 (46%) were treatment success, 248 (31.8%) transferred out, 112 (14.4%) defaulted, 46 (5.9%) died and 15 (1.9%) failed. After controlling other factors, poor TB treatment was associated with age ≥38 years (p=0.003; aOR 1.58; 95% CI 1.2-2.1), previous history of TB treatment (p |
| Databáze: | OpenAIRE |
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