Inhibitory Effects of Complex of Mulberry Extract on Degenerative Arthritis
| Autor: | Jong Moon Jeong, Hyeong Ho Seo |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Traditional medicine
business.industry DPPH education Pharmaceutical Science Arthritis Plant Science Inhibitory postsynaptic potential medicine.disease Biochemistry Genetics and Molecular Biology (miscellaneous) Carrageenan Nitric oxide chemistry.chemical_compound Degenerative arthritis chemistry Edema Glycine Medicine medicine.symptom business Agronomy and Crop Science |
| Zdroj: | Korean Journal of Medicinal Crop Science. 22:262-269 |
| ISSN: | 1225-9306 |
| Popis: | Complex of mulberry extract (CME) is composed of extracts of mulberry (Morus alba L.) fruit, mulberry leaves and black beans (Glycine max (L.) Merr.). In this study, we investigated prevention effects of CME on degenerative arthritis. The SC50 value of DPPH radical scavenging by CME was 158.49 ± 11.35 ㎍/mL. We found that CME significantly reduced the production of nitric oxide (NO) and protein expression of cyclooxygenase-2 (COX-2) in RAW 264.7 cells which were activated by LPS. Experiments using animal model of degenerative arthritis showed that CME (400 ㎎/㎏ body weight) inhibited the production of TNF-α (77.5%) and IL-1β (95.0%). Furthermore, it was observed that CME reduced to 85.9% of paw edema induced by carrageenan. These results suggest that CME could improve degenerative arthritis. |
| Databáze: | OpenAIRE |
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