Improved Delivery through Biological Membranes. Synthesis, Characterization and Antiviral Activity of a Series of Ribavirin Chemical Delivery Systems: 5 and Carboxamide Derivatives
| Autor: | Klara Czako, M. Bhagrath, N. Bodor, Marcus E. Brewster, K. Seyda, Robert W. Sidwell, Wesley Anderson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
0301 basic medicine
biology viruses Ribavirin 030106 microbiology General Medicine medicine.disease biology.organism_classification 01 natural sciences Virology Virus 0104 chemical sciences Dengue fever 010404 medicinal & biomolecular chemistry 03 medical and health sciences chemistry.chemical_compound Phlebovirus chemistry medicine Viral disease Rift Valley fever Lassa fever Encephalitis |
| Zdroj: | Antiviral Chemistry and Chemotherapy. 2:265-286 |
| ISSN: | 2040-2066 |
| DOI: | 10.1177/095632029100200502 |
| Popis: | those agents which are available to the central nervous system (CNS)insignificant amounts for sustained periods. While these problems are apparent with a number of pathogens, RNA viral infections, with the notable excep tion of human immunodeficiency virus (HIV), have gen erally received less attention than DNA viruses. RNA viruses are unique in that they reverse the usual bio chemical DNA~ RNA~ protein sequence which occurs in higher life forms. In addition, RNA viruses precipitate diseases associated with significant mortality and morbi dity, such as dengue fever, Lassa fever, sandfly fever, Rift Valley fever, a variety of haemorrhagic fevers, and a number of encephalitic maladies such as Japanese B encephalitis (Johnson, 1984; Fisher-Hoch and Simpson, 1986). This latter infection is estimated to kill 30 000 people in the Far East each year, while sandfly fever is a major health problem in the Middle East. One notable advance in the treatment of these 'exotic' viral diseases was the development of ribavirin (1-[3-D ribofuranosyl-1,2,4-triazol-3-carboxamide) in the early seventies (Witkowski et al., 1972; L. Christensen and J. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|