ChemInform Abstract: Potent Inhibition of Glycogen Phosphorylase by a Spirohydantoin of Glucopyranose: First Pyranose Analogues of Hydantocidin

Autor:	George W. J. Fleet, Nikos G. Oikonomakos, Mark R. Wormald, Spyros E. Zographos, C. J. F. Bichard, Kimberly A. Watson, Louise N. Johnson, Demetra D. Koutra, E. P. Mitchell
Rok vydání:	2010
Předmět:	Glycogen phosphorylase Anomer Pyranose Stereochemistry Chemistry Epimer General Medicine Specific enzyme Hydantocidin
Zdroj:	ChemInform. 26
ISSN:	0931-7597
DOI:	10.1002/chin.199530243
Popis:	The synthesis of two epimeric spirohydantoins of glucopyranose provides the first examples of pyranose analogues of hydantocidin: molecular modelling correctly predicted that one of the epimers would be a potent inhibitor of glycogen phosphorylase. This is the first example of specific enzyme inhibition by a spirohydantoin at the anomeric position of a sugar.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d898b315c656088e8dadd997a4693274 https://doi.org/10.1002/chin.199530243 Zobrazit plný text záznamu Plný text