Impaired Cognitive Abilities in Siblings of Patients with Temporal Lobe Epilepsy
| Autor: | Lili Long, Yujiao Fu, Min Zhang, Wenbiao Xiao, Kangrun Wang, Chaorong Liu, Bo Xiao, Wenyue Wu, Hongyu Long, Yayu Chen, Ge Wang, Langzi Tan, Jialinzi He |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Working memory Neuropsychology Cognition Audiology Executive functions behavioral disciplines and activities nervous system diseases 030227 psychiatry 03 medical and health sciences 0302 clinical medicine nervous system Endophenotype Digit symbol substitution test Memory span Medicine Block design test business psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Neuropsychiatric Disease and Treatment. 16:3071-3079 |
| ISSN: | 1178-2021 |
| DOI: | 10.2147/ndt.s258074 |
| Popis: | Purpose Patients with temporal lobe epilepsy (TLE) are at high risk of cognitive impairment. In addition to persistent seizures and antiepileptic drugs (AEDs), genetic factors also play an important role in the progression of cognitive deficits in TLE patients. Defining a cognitive endophenotype for TLE can provide information on the risk of cognitive impairment in patients. This study investigated the cognitive endophenotype of TLE by comparing neuropsychological function between patients with TLE, their unaffected siblings, and healthy control subjects. Patients and Methods A total of 46 patients with TLE, 26 siblings, and 33 control subjects were recruited. Cognitive function (ie, general cognition, short- and long-term memory, attention, visuospatial and executive functions, and working memory) was assessed with a battery of neuropsychological tests. Differences between groups were evaluated by analysis of covariance, with age and years of education as covariates. The Kruskal-Wallis test was used to evaluate data that did not satisfy the homogeneity of variance assumption. Pairwise comparisons were adjusted by Bonferroni correction, with a significance threshold of P |
| Databáze: | OpenAIRE |
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