Étude de l’enzyme de conversion de l’angiotensine I et de l’hyperhomocystéinémie chez les coronariens tunisiens
| Autor: | Latifa Chkioua, Y. Chaabouni, A. Chalghoum, A. Dandana, H. Chahed, Y. Noichri, S. Khelil, S. Ferchichi, Z. Jaidane, I. Gammoudi, A. Miled, G. Jeridi |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Hyperhomocysteinemia Homocysteine Vascular disease business.industry Biochemistry (medical) Clinical Biochemistry medicine.disease Control subjects chemistry.chemical_compound Endocrinology chemistry Internal medicine Immunopathology Renin–angiotensin system medicine In patient cardiovascular diseases Risk factor business |
| Zdroj: | Immuno-analyse & Biologie Spécialisée. 25:185-190 |
| ISSN: | 0923-2532 |
| DOI: | 10.1016/j.immbio.2010.05.007 |
| Popis: | Summary Background The acute coronary syndromes (ACS) are polygenic and complex pathologies. The increase of angiotensin I converting enzyme (ACEI) activity and homocysteinemia (hcy) are supposed to be risk factor. Aim To evaluate the ACEI activity and hcy in patients with coronary disease. Patients and methods Ninety-eight patients and 76 control subjects are recruited for our study. ACEI activity was measured by kinetic method. hcy was determined by Fluorescence Polarization Immunoassay (FPIA). Results An increased of ACEI activity and hcy was observed in patients compared with control subjects (ECAI: 83.8 ± 29.9 UI/L vs 57.6 ± 15.2 UI/L, P −5 ; hcy: 25.6 ± 4.2 μmol/L vs 9.82 ± 3.11 μmol/L, P = 10 −3 ). In patients, ACEI was negatively correlated with hcy. Conclusion The increased of ACEI activity and hyperhomocystenemia can be considered as a non-classic risk factors. |
| Databáze: | OpenAIRE |
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