Scleromyxedema histopathologically mimicking hypercellular fibrous papules (angiofibomas): Case report of an unusual histopathological presentation

Autor:	Viktoryia Kazlouskaya, Edward Heilman, Neelam Khan
Rok vydání:	2020
Předmět:	medicine.medical_specialty Pathology Histology business.industry CD68 Mucin Dermatology Angiofibroma medicine.disease Angiofibromas Colloidal iron Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Scleromyxedema medicine Histopathology Factor XIIIa business
Zdroj:	Journal of Cutaneous Pathology. 47:638-642
ISSN:	1600-0560 0303-6987
DOI:	10.1111/cup.13665
Popis:	Scleromyxedema (SMX) is an inflammatory condition of unknown etiology strongly associated with monoclonal gammopathy. Classical histopathology of SMX is characterized with the triad of diffuse mucin deposits, increased amount of collagen, and presence of stellate fibroblasts. Herein, we report an unusual histopathological variant of SMX in a 41-year-old female with lesions of the nose histopathologically mimicking cellular angiofibromas. The dome-shaped papules were characterized by increased collagen bundles and fascicles of spindle cells. Widened vessels were seen at the periphery of the proliferation. Cells expressed CD68. Factor XIIIa was expressed only by dendritic cells. The mucin was highlighted with colloidal iron. In sum, we draw attention to this unusual variant of SMX, which should be suspected in a setting of multiple "angiofibromas/fibrous papules" on the face with presence of mucin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d88d31941864a494f9686aa46d1a73f6 https://doi.org/10.1111/cup.13665 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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