Hepcidin-Guided Screen-and-Treat Interventions Against Iron Deficiency Anaemia in Pregnancy: A Randomised Controlled Trial in Gambian Women
| Autor: | Hal Drakesmith, Andrew E. Armitage, James H. Cross, Abdul Khalie Muhammad, Ebrima A. Sise, Sant-Rayn Pasricha, Amat Bah, Andrew M. Prentice, Morgan M. Goheen, Rita Wegmüller, Carla Cerami, Saikou Sanyang, Hans Verhoef, Sophie E. Moore, Ebrima Danso |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
biology Transferrin saturation business.industry Iron deficiency medicine.disease law.invention Clinical trial Randomized controlled trial Hepcidin law Internal medicine medicine Clinical endpoint biology.protein Data monitoring committee business Soluble transferrin receptor |
| Zdroj: | SSRN Electronic Journal. |
| ISSN: | 1556-5068 |
| Popis: | Background: Iron deficiency is the most prevalent nutritional deficiency worldwide. WHO recommends daily iron supplementation for all pregnant women where anaemia exceeds 40%, but adherence is limited by side-effects, effectiveness is low, and there are concerns around possible harm. The iron-regulatory hormone, hepcidin, signals 'ready-and-safe' to receive iron. We tested a hepcidin-guided screen-and-treat (S&T) approach to combat iron deficiency anaemia (IDA) aimed at achieving equivalent efficacy to universal administration but at lower levels of supplemental iron exposure. Methods: We conducted a 3-arm randomised-controlled double-blind trial in rural Gambia to assess non-inferiority of two ST b) daily UNIMMAP containing 60mg iron for 7d if weekly hepcidin was |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|