A resolution of the monodentate P*-chiral phosphine PButC6H4Br-4 and its NMR-deduced absolute configuration

Autor:	Marina Yu. Rubina, Lyudmila G. Kuzmina, Valery V. Dunina, Elena I. Kazakova, Yuri K. Grishin, Yuri A. Veits
Rok vydání:	1999
Předmět:	Denticity Stereochemistry Organic Chemistry Diastereomer Absolute configuration chemistry.chemical_element Catalysis Inorganic Chemistry Crystallography chemistry.chemical_compound Enantiopure drug Benzylamine chemistry Proton NMR Physical and Theoretical Chemistry Phosphine Palladium
Zdroj:	Tetrahedron: Asymmetry. 10:1483-1497
ISSN:	0957-4166
DOI:	10.1016/s0957-4166(99)00134-2
Popis:	Both enantiomers of the monodentate phosphine PBu t C 6 H 4 Br-4 were obtained in an enantiopure state by chromatographic separation of their diastereomeric adducts with a new homochiral ortho -palladated resolving agent derived from α- tert -Bu-substituted tertiary benzylamine. The conformation of the palladacycle and the absolute configuration of the phosphine were determined using 1 H NMR spectroscopy (including NOE technique) and confirmed by an X-ray diffraction study of both diastereomeric complexes. The enantiomers of the resolved phosphine were displaced from the individual diastereomers of the palladium(II) complexes with recovery of the starting resolving agent, and trapped in the form of binuclear coordination complexes of palladium(II).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d88585fbd45dce635e03e5df1e9bd40a https://doi.org/10.1016/s0957-4166(99)00134-2 Zobrazit plný text záznamu Full Text from ScienceDirect