Secretory reactions of cultured hypophyseal growth hormone-producing adenoma cells to somatoliberin and somatostatin
| Autor: | S. Yu. Serpukhovitin, S. Yu. Kasumova, Elizarova Gp, T. A. Osipova, Komolov Is, A. A. Bulatov |
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| Rok vydání: | 1997 |
| Předmět: |
endocrine system
medicine.medical_specialty Adenoma Chemistry General Medicine medicine.disease Somatoliberin General Biochemistry Genetics and Molecular Biology Growth hormone secretion Prolactin Prolactin cell Somatostatin Endocrinology Internal medicine medicine Secretion hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 123:279-282 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02445426 |
| Popis: | Somatoliberin stimulates secretion of growth hormone and has no effect on secretion of prolactin in primary cultures of hypophyseal adenoma cells obtained from acromegalic patients. A short-term contact of the cells with somatostatin inhibits secretion of growth hormone, while a long-term contact with this hormone inhibits prolactin production. Somatoliberin abolishes the inhibitory effect of somatostatin on the growth hormone secretion and at high concentrations stimulates it. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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