| Autor: | H. A. El-Obeid, A. E. Madani, M. E. Ibrahim, K. E. H. El Tahir, Khalid A. Al-Rashood, Abdul Karim Tilmisani |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Pharmacology
Lagomorpha Contraction (grammar) biology Stereochemistry Organic Chemistry Pharmaceutical Science chemistry.chemical_element Biological activity Propranolol Calcium biology.organism_classification Atropine chemistry medicine Molecular Medicine Pharmacology (medical) medicine.symptom Biotechnology Metoprolol medicine.drug Muscle contraction |
| Zdroj: | Pharmaceutical Research. :166-170 |
| ISSN: | 0724-8741 |
| DOI: | 10.1023/a:1016435523349 |
| Popis: | A series of N-alkyl-l,2-diphenylethanolamines were synthesized and their pharmacological activities evaluated on various mammalian organs and sytems. All compounds produced a generalized inhibitory effect on smooth and cardiac muscles and an increase in coronary flow as well as a brief reduction in rabbit blood pressure. The latter effect was not prevented by pretreatment of the animals with atropine, propranolol, or metoprolol. The compounds were devoid of local anesthetic activity and their inhibitions of the contraction of the isolated rabbit intestine and perfused heart were reversed by exogenous calcium ions. It is proposed that the compounds produce their effects through calcium-channel blockade. The inhibitory effects of some of these compounds were comparable to those of a known calcium-channel blocker. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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