Comparison of Some In Vitro Measurements of Membrane Damage to Corneal Epithelial Cells

Autor:	Josephine W. Cheng, Claude B. Anger, Steven S. Matsumoto, David C. Rupp, Michael E. Stern
Rok vydání:	1997
Předmět:	Cell Hydroxyeicosatetraenoic acid In vitro Cell biology Cell membrane chemistry.chemical_compound medicine.anatomical_structure Membrane chemistry Cornea cardiovascular system medicine lipids (amino acids peptides and proteins) Arachidonic acid Sodium dodecyl sulfate
Zdroj:	Advances in Ocular Toxicology ISBN: 9781461377207
DOI:	10.1007/978-1-4615-5937-5_22
Popis:	Surfactants may interact with cell membranes of the cornea during use of ophthalmic products or as a result of accidental exposure. Inflammatory mediators including the eicosanoids, prostaglandins and hydroxyeicosatetraenoic acids (HETE), are released from the corneain vivoas a response to chemical and mechanical injury.1-4The production of eicosanoids by cultured corneal cells has been used as anin vitromodel for the ocular response to acute injury caused by surfactants.5-7The present study compared thein vitroproduction of eicosanoids to two otherin vitromeasurements of cell membrane damage, vital dye staining8and intracellular calcium ion concentrations.9
Databáze:	OpenAIRE
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