THU0252 Nailfold capillaroscopy in systemic lupus erythematosus: a systematic review and critical appraisal
| Autor: | Ulf Müller-Ladner, Maurizio Cutolo, Nicola Ughi, Francesca Ingegnoli, Valeria Riccieri, Saskia Decuman, Kristof Thevissen, Oliver Distler, Yves Piette, Sara R.A. Wijnant, Ellen Deschepper, F De Keyser, Vanessa Smith, Karin Melsens, Els Vandecasteele |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gangrene Pathology medicine.medical_specialty Proteinuria business.industry Disease 030204 cardiovascular system & hematology Acr criteria medicine.disease Dermatology Scleroderma 03 medical and health sciences Critical appraisal 030104 developmental biology 0302 clinical medicine Quality appraisal medicine medicine.symptom skin and connective tissue diseases business Nailfold Capillaroscopy |
| Zdroj: | Poster Presentations. |
| DOI: | 10.1136/annrheumdis-2017-eular.2920 |
| Popis: | Background Systemic lupus erythematosus (SLE) is a rheumatic disease with common vascular involvement. Nailfold capillaroscopic changes have been described in SLE. Although, until today there is no clear role yet for capillaroscopy in classifying or staging the disease. Objectives To systematically review and critically appraise the literature on capillaroscopic changes described in SLE. Methods A sensitive search, on behalf of the EULAR study group on microcirculation in Rheumatic Diseases, was developed in Web Of Science, PubMed and Embase to identify all original research studies in which SLE patients had capillaroscopy. Two reviewers identified titles, abstracts and full texts. Exclusion criteria were: ACR criteria for SLE were not met, less than 5 patients were included in the study, there was no information on capillaroscopy in SLE, no original research or non-English language. All included articles underwent quality appraisal. Results were summarised according to density, dimensions, morphology, haemorrhages, semi quantitative assessment, qualitative assessment (see table) and correlation of capillaroscopic changes with clinical and laboratory parameters. Results From 172 articles captured, 36 articles were included in this review. The following capillaroscopic parameters were significantly more prevalent in SLE patients compared to healthy controls (see table): tortuous capillaries, abnormal morphology, haemorrhages, nailfold capillaroscopic score, “non-specific patterns” and “scleroderma like pattern”. Hairpin shaped capillaries were significantly more prevalent in healthy controls compared to SLE patients. For clinical and laboratory parameters, Raynaud9s phenomenon (RP), gangrene and 24 hours proteinuria were significantly correlated with capillaroscopic changes. Conclusions This first systematic review on capillaroscopy in SLE attests conclusive significant differences in morphology, haemorrhages, semi quantitative assessment, qualitative assessment and some clinical and laboratory parameters. Further large scale research is ongoing through the EULAR study group on microcirculation in Rheumatic Diseases to further define its role. Disclosure of Interest None declared |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|