Asymmetric diels alder reaction using pyrazole derivatives as a chiral catalyst

Autor:	Choji Kashima, Saori Shibata, Yohei Miwa, Hiroyuki Nakazono
Rok vydání:	2003
Předmět:	chemistry.chemical_compound Chemistry Organic Chemistry Pyrazole Medicinal chemistry Methane Diels–Alder reaction Catalysis
Zdroj:	Journal of Heterocyclic Chemistry. 40:681-688
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570400420
Popis:	N-Acylpyrazoles (1) were promising as good dienophiles, which were easily converted into the desired carboxylic derivatives. Bis(pyrazolyl)methanes, which were derived from chiral pyrazoles, showed the activity of chiral catalyst. Particularly 10 mol% of bis(isomenthopyrazol-1,1′-yl)methane (8a) catalyzed enantioselectively the Diels Alder reaction up to 40 % ee by the formation of complex with Mg(ClO4)2.
Databáze:	OpenAIRE
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