| Autor: |
Jiwon Choi, Yangmee Kim, Jin-Kyoung Kim, Ki-Woong Jeong, Byung-Ha Chang, Jee-Young Lee |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Bulletin of the Korean Chemical Society. 33:2907-2909 |
| ISSN: |
0253-2964 |
| DOI: |
10.5012/bkcs.2012.33.9.2907 |
| Popis: |
A disintegrin and metalloprotease with thrombospondin domains (ADAMTS) are a member of peptidase and involved in processing of von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan. Among 19 subfamilies of human ADAMTS, ADAMTS-4 is a zinc-binding metalloprotease and is a famous therapeutic target for arthritis. It has been reported that a flavonoid luteolin shows inhibitory activity against ADMATS-4. In this study, we verified that luteolin is a potent inhibitor of ADAMTS-4 and probed the molecular basis of its action. On the basis of a docking study, we proposed a binding model between luteolin and ADAMTS-4 in which 3',4'-dihydroxyl groups in luteolin formed hydrogen bonding with ADMATS-4 and these interactions are important for its inhibitory activity against ADAMTS-4. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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