Studies on the natriuretic effect and site of action of indapamide
| Autor: | Charles Swartz, K. E. Kim, Gaddo Onesti, D. L Lowenthal, J. Pitone, Jane Shirk, B. J Bronstein, Eduardo W. Martinez, E. Valvo, Melton B. Affrime, M. Fernandes |
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| Rok vydání: | 1977 |
| Předmět: | |
| Zdroj: | Current Medical Research and Opinion. 5:83-88 |
| ISSN: | 1473-4877 0300-7995 |
| DOI: | 10.1185/03007997709110228 |
| Popis: | SummaryA double-blind, placebo-controlled study was carried out in 42 normal male volunteers to determine the natriuretic effect of indapamide in increasing doses. After α 3-day period of dietary stabilization on relatively high sodium intake and unlimited water intake, groups of 6 subjects were given single doses of placebo or 0.5 mg, 1.0 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, or 30 mg indapamide. Urinary volume and electrolyte excretion were measured for the periods 0 to 4 hours, 4 to 8 hours, and 8 to 24 hours after drug administration. No natriuretic effect was evident with 0.5 mg indapamide. With doses of 2.5 mg and 5 mg, there was a significant progressive increase in sodium excretion but not of potassium. Doses of 10 mg and 20 mg continued to show this pattern but the natriuretic effect was not greater on a 24-hour basis than with the 5 mg dose. No further increase in natriuresis was observed with 30 mg indapamide, but there was a significant kaliuresis and a marked increase in urinary volume.In a study i... |
| Databáze: | OpenAIRE |
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