Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in Inflammatory Bowel Disease
| Autor: | Edwin F. deZoeten, Daniel J. Kao, Kayla D. Battista, Robert W Isfort, Steven B. Colson, Alyson Yeckes, Mark E. Gerich, Simon Keely, Joseph C. Onyiah, Sean P. Colgan, Edward J. Hoffenberg, Brittelle E. Kessler, Blair Fennimore, Monica Murray, Mark A. Lovell |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Crohn's disease
medicine.medical_specialty business.industry Inflammation Hypoxia (medical) medicine.disease Inflammatory bowel disease Gastroenterology Ulcerative colitis 3. Good health Vascular endothelial growth factor 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Internal medicine medicine Histopathology 030212 general & internal medicine medicine.symptom Colitis business |
| Zdroj: | Hypoxia. 8:1-12 |
| ISSN: | 2324-1128 |
| DOI: | 10.2147/hp.s219049 |
| Popis: | Background Inflammation results in significant shifts in tissue metabolism. Recent studies indicate that inflammation and hypoxia occur concomitantly. We examined whether circulating and tissue markers of hypoxia could serve as surrogate indicators of disease severity in adult and pediatric patients with inflammatory bowel disease (IBD). Methods Serum and colonic biopsies were obtained from pediatric subjects with active IBD colitis and adult subjects with active and inactive ulcerative colitis, along with healthy non-colitis controls of all ages. Disease activity was evaluated by endoscopy and histopathology. Levels of serum hypoxia markers (macrophage inflammatory protein-3α [MIP-3α], vascular endothelial growth factor [VEGF], and erythropoietin [EPO]) were measured. Results Children with active IBD colitis had higher levels of serum MIP-3α and VEGF compared to non-colitis controls (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|