Highly efficient synthesis and antioxidant capacity of N-substituted benzisoselenazol-3(2H)-ones

Autor:	Agata J. Pacuła, Jacek Ścianowski, Krzysztof Aleksandrzak
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Antioxidant Ebselen General Chemical Engineering medicine.medical_treatment Aryl chemistry.chemical_element General Chemistry Diselenide chemistry.chemical_compound Antioxidant capacity chemistry medicine Organic chemistry Lithium Alkyl
Zdroj:	RSC Adv.. 4:48959-48962
ISSN:	2046-2069
Popis:	A new, general one step synthesis of N-substituted benzisoselenazol-3(2H)-ones based on the reaction of o-iodobenzamides with lithium diselenide, is described. A series of alkyl and aryl derivatives was obtained in high yields (up to 98%). Their GPx-like antioxidant activity, tested by NMR, showed a significantly higher activity than ebselen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d85c1fc9d2d1ce8f68cfa97bdb228c23 https://doi.org/10.1039/c4ra08631g Zobrazit plný text záznamu