Highly efficient synthesis and antioxidant capacity of N-substituted benzisoselenazol-3(2H)-ones
Autor: | Agata J. Pacuła, Jacek Ścianowski, Krzysztof Aleksandrzak |
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Rok vydání: | 2014 |
Předmět: | |
Zdroj: | RSC Adv.. 4:48959-48962 |
ISSN: | 2046-2069 |
Popis: | A new, general one step synthesis of N-substituted benzisoselenazol-3(2H)-ones based on the reaction of o-iodobenzamides with lithium diselenide, is described. A series of alkyl and aryl derivatives was obtained in high yields (up to 98%). Their GPx-like antioxidant activity, tested by NMR, showed a significantly higher activity than ebselen. |
Databáze: | OpenAIRE |
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