Fibre-reinforced biocompatible hydrogel to replace single-use plastic tubing in the clinical setting
| Autor: | Erika M. J. Siren, Masoud Daneshi, Anthony Wachs, R. Melnick, T. Treskatis, Jordan MacKenzie, D.M. Martinez, Jayachandran N. Kizhakkedathu |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
0303 health sciences
Single use Materials science Human blood Hospital setting Manufacturing process General Chemical Engineering Platelet adhesion 02 engineering and technology General Chemistry 021001 nanoscience & nanotechnology Biocompatible material Industrial and Manufacturing Engineering 03 medical and health sciences Environmental Chemistry Extrusion Composite material 0210 nano-technology 030304 developmental biology |
| Zdroj: | Chemical Engineering Journal. 428:131786 |
| ISSN: | 1385-8947 |
| DOI: | 10.1016/j.cej.2021.131786 |
| Popis: | In this work we examine a manufacturing process to produce hydrogel tubing for extracorporeal applications. In the first study we examine the methodology to scale-up extrusion printers to inertial flow conditions. We advance bounds to maintain hydrodynamic stability through direct numerical simulation which are verified experimentally. Using these bounds, we develop three different 3D-extrusion printers operating with speeds of up to 12 cm/s. In the second study, we explore the use of these printers by producing biodegradable hydrogel tubing. When reinforced with 1% cellulose fibre, these tubes are sufficiently tough to circulate human blood for 200 h with marginal spallation and display a 6-fold decrease in platelet adhesion. This is a promising first step to reduce cardiovascular complications and to replace single-use plastic tubing in the hospital setting. |
| Databáze: | OpenAIRE |
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