A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin

Autor:	Richard J. Mitchell, Sarah M. Kriger, Alexander D. Fenton, Dmytro Havrylyuk, Ankit Pandeya, Yang Sun, Tami Smith, Jason E. DeRouchey, Jason M. Unrine, Viral Oza, Jessica S. Blackburn, Yinan Wei, David K. Heidary, Edith C. Glazer
Rok vydání:	2023
Předmět:	Chemistry (miscellaneous) Biochemistry Genetics and Molecular Biology (miscellaneous) Molecular Biology Biochemistry
Zdroj:	RSC Chemical Biology. 4:344-353
ISSN:	2633-0679
DOI:	10.1039/d2cb00247g
Popis:	Phenanthriplatin forms DNA mono-adducts and induces ribosome biogenesis stress. Using a semi-rational strategy, Ru(ii) complexes were created that act as biological mimics of phenanthriplatin with improved properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d858fd26c8b8445e3028892a060bcf52 https://doi.org/10.1039/d2cb00247g Zobrazit plný text záznamu