| Autor: |
M. Davies, M. H. T. Roberts |
| Rok vydání: |
1990 |
| Předmět: |
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| Zdroj: |
Cardiovascular Pharmacology of 5-Hydroxytryptamine ISBN: 9789401067010 |
| DOI: |
10.1007/978-94-009-0479-8_13 |
| Popis: |
Most evidence for a role of 5-hydroxytryptamine (5-HT) in hypertension points to an action on the blood vessel wall [1] but many compounds acting on 5-HT receptors also penetrate the blood-brain barrier and central neuronal receptors to 5-HT significantly affect sympathetic outflows [2, 3]. Undoubtedly, the central actions at 5-HT receptors of some antihypertensive agents are of relevance to their therapeutic actions. Until recently the actions of 5-HT on central neurones have been ill defined and controversial due to the lack of a proper framework of receptor definition and a lack of drugs which discriminate between receptor types. Selective agonists and antagonists have been developed in the last decade and the proposed classification of 5-HT receptor types by Bradley et al. [4] has enabled studies of central functional receptors to 5-HT. However, lack of selective antagonists at the 5-HT1-like receptor continues to inhibit proper definition of 5-HT actions in the CNS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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