Significant counterion effect of the In(III)–pybox complex in highly enantioselective carbonyl-ene reactions of ethyl glyoxylate
Autor: | Junfeng Zhao, Teck-Peng Loh, Teguh‐Budiono W. Tjan |
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Rok vydání: | 2010 |
Předmět: | |
Zdroj: | Tetrahedron Letters. 51:5649-5652 |
ISSN: | 0040-4039 |
Popis: | A highly efficient enantioselective carbonyl-ene reaction of ethyl glyoxylate catalyzed by an In(III)–pybox complex, which is designed based on the counterion effect, is reported. Reactions of both aliphatic and aromatic 1,1-disubstituted olefins proceed smoothly to give enantioenriched homoallylic alcohols with excellent yields and enantioselectivities. In addition, electron-withdrawing as well as donating groups on the phenyl ring of α-methyl styrenes are tolerated in this reaction. |
Databáze: | OpenAIRE |
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