Significant counterion effect of the In(III)–pybox complex in highly enantioselective carbonyl-ene reactions of ethyl glyoxylate

Autor:	Junfeng Zhao, Teck-Peng Loh, Teguh‐Budiono W. Tjan
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry Organic Chemistry Drug Discovery Enantioselective synthesis Glyoxylate cycle Organic chemistry Counterion Ring (chemistry) Biochemistry Ene reaction Catalysis
Zdroj:	Tetrahedron Letters. 51:5649-5652
ISSN:	0040-4039
Popis:	A highly efficient enantioselective carbonyl-ene reaction of ethyl glyoxylate catalyzed by an In(III)–pybox complex, which is designed based on the counterion effect, is reported. Reactions of both aliphatic and aromatic 1,1-disubstituted olefins proceed smoothly to give enantioenriched homoallylic alcohols with excellent yields and enantioselectivities. In addition, electron-withdrawing as well as donating groups on the phenyl ring of α-methyl styrenes are tolerated in this reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d8480966a2e81095559d528e05d313d1 https://doi.org/10.1016/j.tetlet.2010.06.066 Zobrazit plný text záznamu Full Text from ScienceDirect