Evaluating subjective domains of antipsychotic-induced adverse effects using heart rate variability
| Autor: | Yong Sik Kim, Jae Seung Chang, Yu Sang Lee, Sang Hoon Yi, Yeni Kim, Hee-Yeon Jung, Samuel Suk Hyun Hwang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Positive and Negative Syndrome Scale medicine.drug_class General Neuroscience medicine.medical_treatment General Medicine Audiology medicine.disease Sample entropy Psychiatry and Mental health Neurology Rating scale Schizophrenia Anticholinergic medicine Heart rate variability Neurology (clinical) Adverse effect Psychology Antipsychotic Clinical psychology |
| Zdroj: | Psychiatry and Clinical Neurosciences. 69:283-291 |
| ISSN: | 1323-1316 |
| DOI: | 10.1111/pcn.12226 |
| Popis: | Aims Antipsychotic-induced autonomic dysregulation may lead to a wide range of subjective side-effects in schizophrenia patients. Using heart rate variability (HRV) measures, we prospectively examined the relationship between subjective side-effects and cardiac autonomic regulation in unmedicated schizophrenia patients. Methods Forty-five unmedicated schizophrenia patients were assessed for antipsychotic-associated side-effects and HRV parameters at baseline and after 6 weeks of treatment. Psychiatric symptoms and subjective side-effects were assessed using the Positive and Negative Syndrome Scale (PANSS) and the Liverpool University Neuroleptic Side-effect Rating Scale (LUNSERS). Results Correlations between subjective adverse effects and HRV measures at baseline and at week 6 varied. Nonetheless, the changes in the psychic side-effects domain were significantly correlated with the changes in time-domain HRV measures and sample entropy (SampEn). In addition, the change in SampEn was significantly associated with that in the scores of extrapyramidal, anticholinergic, miscellaneous, and red herring domains as well as the mean total LUNSERS score. Conclusion Baseline HRV measures may predict clinical response and adverse events associated with treatment adherence. Also, subjective side-effects may correspond well with the changes in neurocardiac dynamics, and the changes in SampEn may effectively reflect subjective discomfort in patients receiving antipsychotic treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text