Predictors of death in patients with MDR-TB and HIV
| Autor: | Sergey Saenko, Larisa Rusakova, Sergey Sterlikov |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Hepatitis
medicine.medical_specialty Tuberculosis biology business.industry Retrospective cohort study Drug resistance biology.organism_classification Logistic regression medicine.disease Mycobacterium tuberculosis Multiple drug resistance 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Internal medicine medicine 030212 general & internal medicine business Body mass index |
| Zdroj: | Tuberculosis. |
| DOI: | 10.1183/13993003.congress-2020.1599 |
| Popis: | Background: Tuberculosis with multiple drug resistance of Mycobacterium tuberculosis in combination with HIV-infection (MDR-TB/HIV) is characterized by high mortality. Methods: In the retrospective cohort study with one-year follow-up of 130 MDR-TB/HIV patients, potential predictors of death were studied: age, gender, body mass index (BMI), history of previous treatment, adherence to treatment, CD4+ level in 1 µl, drug resistance, liver size, hemoglobin and protein levels in g/l, hepatitis, alcohol and drug addiction, homelessness. For quantitative characteristics, median values were calculated for groups of patients who lived for more than one year of follow-up (L) and died within one year of follow-up (D). Results: 31 patients – 23.9% died. Statistically significant differences were obtained for: homelessness (OR=4.8; p=0.05), alcohol and drugs addiction (for alcoholism, OR=2.4; p=0.05; for drug addiction, OR=2.8; p=0.02), history of being lost to follow-up (OR=4.7; p=0.05), BMI (L=29; D=19; p=0.001), number of CD4+ (L=334; D=117; p=0.001), hemoglobin level (l=133; d=122; p=0.03) and the total protein (l=77; d=22; p=0.006). Subsequent logistic regression analysis revealed the significance of the following factors: history of being lost to follow-up (p=0.01), level of CD4+ (p=0.02), body mass index (p=0.08). Conclusion: The most important predictors of death MDR-TB/HIV patients include history of being lost to follow-up, low CD4+, and low BMI. |
| Databáze: | OpenAIRE |
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