Effect of Phyllanthus niruri Extract on Low Density Lipoprotein of Dyslipidemic White Rats (Rattus norvegicus)
| Autor: | Ahmad Ghozali, Andre Stefanus, Anastasia Feliciana, Rita Cempaka S, Indrawati F, Felix Ev, Iin Suryanti, Yosua Anthony P |
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| Rok vydání: | 2019 |
| Předmět: |
Phyllanthus
biology medicine.diagnostic_test Pharmacology biology.organism_classification medicine.disease chemistry.chemical_compound Rutin chemistry Simvastatin Low-density lipoprotein medicine lipids (amino acids peptides and proteins) Lipid profile Quercetin Dyslipidemia medicine.drug Lipoprotein |
| Zdroj: | Herbal Medicine: Open Access. |
| DOI: | 10.36648/2472-0151.5.2.100044 |
| Popis: | Background: Dyslipidemia is a lipid metabolism disorder characterized by elevated levels of total cholesterol, Low Density Lipoprotein (LDL) and triglycerides and a decrease in high-density lipoprotein (HDL). Meniran contains tannins, saponins, alkaloids, rutin and quercetin, which have hypolipidemia effect. Objective: This study aimed to observe the effect of meniran extract on the Low Density Lipoprotein (LDL) in Wistar rats, compared with simvastatin. Methods: Thirty-five Wistar rats (Rattus novergicus) were divided into five groups, then all were induced with American Diet 2 (AD2) high fat modification diet for 60 days, except the control group I. Then during the next 60 days, groups I and II were not given any treatment, group III was given simvastatin 0.8 mg/200 g body weight (BW)/ day, group IV was given meniran extract 50 mg/200 g BW/day and group V was given meniran extract 100 mg/200 g BW/day. Results: Meniran therapy 50 mg/200 g BW/day was better in lowering LDL level than meniran dose 100 mg/200 g BW/day. Meniran therapy, which was significantly (p |
| Databáze: | OpenAIRE |
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