Abstract P084: Racial Variation in Stroke Risk by Stroke Risk Factors
| Autor: | Monik C Jimenez, JoAnn E Manson, Nancy Cook, Ichiro Kawachi, Sylvia Wassertheil-Smoller, Bernhard Haring, Rami Nassir, Jinnie J Rhee, Shawnita Sealy-Jefferson, Kathryn M Rexrode |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Circulation. 135 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Background: Black American adults exhibit a greater risk of stroke and disproportionate burden of stroke risk factors; however, it is unclear whether these stroke risk factors differentially impact stroke risk by race. Methods: In total, 126,018participants of the Women’s Health Initiative (11,389 black women and 114,629 white women), free of stroke and coronary heart disease at baseline (1993-1998), were followed for up to 17 years through 2010. Participants completed baseline clinical exams with standardized measurements of blood pressure and anthropometrics, medication inventory and self-reported questionnaires on socio-demographic, lifestyle/behaviors, diet and medical history. Incident total strokes were updated annually by questionnaire and confirmed by medical records. Multivariable Cox models estimated racial disparities in stroke overall and by across stroke risk factors. Results: We observed 4,344 stroke events over 1,496,314 person-years (py). In age-adjusted analyses, black women exhibited a 47% greater risk of total stroke compared to white women (hazard ratio [HR]=1.47, 95% CI: 1.33-1.63), which was attenuated toward the null (HR=1.05, 95% CI: 0.94-1.17) by further adjustment for stroke risk factors, which may be considered to be on the biological causal pathway. Disparities in stroke were two-fold higher for younger black (50- Conclusions: Black women exhibited a significantly greater risk of total stroke compared to white women. Importantly, racial disparities were greatest among younger women aged 50 |
| Databáze: | OpenAIRE |
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