| Autor: |
Pejman Soroosh, Satoshi Yamaki, Kazuo Sugamura, Shouji Ine, Naoto Ishii, Takeshi Sasaki, Takeshi Kawabe, Masaki Nio, Hironori Kudo, Hideo Harigae, Nobu Suzuki, Hiroyuki Nagashima, Takanori So, Shu Lan Sun, Motoshi Wada, Seyed Fazlollah Mousavi, Yuko Okuyama |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
European Journal of Immunology. 44:3015-3025 |
| ISSN: |
0014-2980 |
| DOI: |
10.1002/eji.201444701 |
| Popis: |
T-cell homeostasis preserves the numbers, the diversity and functional competence of different T-cell subsets that are required for adaptive immunity. Naive CD4+ T (TN) cells are maintained in the periphery via the common γ-chain family cytokine IL-7 and weak antigenic signals. However, it is not clear how memory CD4+ T-cell subsets are maintained in the periphery and which factors are responsible for the maintenance. To examine the homeostatic mechanisms, CFSE-labeled CD4+CD44highCD62Llow effector memory T (TEM) cells were transferred into sublethally-irradiated syngeneic C57BL/6 mice, and the systemic cell proliferative responses, which can be divided distinctively into fast and slow proliferations, were assessed by CFSE dye dilution. We found that the fast homeostatic proliferation of TEM cells was strictly regulated by both antigen and OX40 costimulatory signals and that the slow proliferation was dependent on IL-7. The simultaneous blockade of both OX40 and IL-7 signaling completely inhibited the both fast and slow proliferation. The antigen- and OX40-dependent fast proliferation preferentially expanded IL-17-producing helper T cells (Th17 cells). Thus, OX40 and IL-7 play synergistic, but distinct roles in the homeostatic proliferation of CD4+ TEM cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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