Enzymatic synthesis of 11C-pyruvic acid and 11C-L-lactic acid
| Autor: | Norman S. Macdonald, Joseph S. Cook, Leonard Spolter, Marvin B. Cohen, Chia C. Chang |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
chemistry.chemical_classification
Radiation biology food and beverages Fatty acid Cofactor Lactic acid Metabolic pathway chemistry.chemical_compound Nuclear Energy and Engineering chemistry Biochemistry Oxidoreductase biology.protein Radiology Nuclear Medicine and imaging Glycolysis Pyruvic acid Anaerobic exercise |
| Zdroj: | The International Journal of Applied Radiation and Isotopes. 31:45-49 |
| ISSN: | 0020-708X |
| DOI: | 10.1016/0020-708x(80)90229-x |
| Popis: | L -Lactic acid is formed as the end product of glycolysis under anaerobic conditions in all cells, but this reaction is of special significance in the myocardium. L -Lactic acid is reversibly formed from and is in equilibrium with myocardial pyruvic acid, which is its sole metabolic pathway. 11C-Pyruvic acid is synthesized from 11C carbon dioxide using pyruvate-ferredoxin oxidoreductase and coenzymes. The 11C-pyruvic acid is then converted to 11C- L -lactic acid by lactic acid dehydrogenase. The availability of 11C-pyruvic acid and 11C- L -lactic acid will permit the in vivo investigation of lactate metabolism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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