Contrast agent free detection of bowel perforation using chlorophyll derivatives from food plants
| Autor: | Hoonsoo Kang, In-Wook Hwang, Jee-Bum Lee, Jung Hyun Han, Yong-Chul Kim, Young Goun Jo, Jung Chul Kim |
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| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Chemistry General Physics and Astronomy 04 agricultural and veterinary sciences Bowel perforation 040401 food science Fluorescence spectra Animal Organs Chlorophyll derivatives Autofluorescence 0404 agricultural biotechnology medicine Physical and Theoretical Chemistry Physiological saline Abdominal surgery |
| Zdroj: | Chemical Physics Letters. 643:10-15 |
| ISSN: | 0009-2614 |
| DOI: | 10.1016/j.cplett.2015.11.005 |
| Popis: | Chlorophylls occur abundantly in food plants and show bright emission bands at long-wavelength regions (∼675 and ∼720 nm) compared to the autofluorescence of animal organs and peritoneal fluids. The use of these emissions as biomarkers for monitoring bowel perforation with a modality that does not involve synthetic contrast agents seems promising. To validate this, we measured the fluorescence spectra of rat organs, human peritoneal and intestinal fluids, and human intestinal fluids diluted with physiological saline. The developed technique showed a high detection sensitivity (∼50 ppm) under irrigation for abdominal surgery, highlighting the potential of this tool in the surgical setting. |
| Databáze: | OpenAIRE |
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