The hypoxic ventilatory response is blunted at 12-15 months corrected age in babies born very preterm
| Autor: | Graham L. Hall, Shannon J. Simpson, Andrew C. Wilson, Naomi Hemy, J. Jane Pillow |
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| Rok vydání: | 2019 |
| Předmět: |
business.industry
First year of life Hypoxic ventilatory response Hypoxia (medical) Mean difference Very preterm 03 medical and health sciences Postnatal age 0302 clinical medicine Corrected Age 030228 respiratory system Control of respiration Anesthesia medicine 030212 general & internal medicine medicine.symptom business |
| Zdroj: | Neonatology and paediatric intensive care. |
| Popis: | Introduction: Babies born preterm have altered control of breathing and a blunted hypoxic ventilatory response (HVR) in early postnatal life. We aimed to assess the HVR at 12-15 months corrected postnatal age (PNA) and determine any lasting effects of neonatal exposures on the HVR. Methods: The HVR was evaluated in infants born Results: Preterm infants (N=39; 16 with BPD) were studied at a mean (SD) age of 14.4 (1.0) months corrected PNA. A small HVR was observed as increased VT (mean difference hypoxic minute 1 from baseline =0.84 mL/kg) and consequently increased VT/Ttot (4.31 mL/s), VT/Ti (9.19 mL/s) and VE (25.98 mL/min/kg); all p Conclusion: Some infants born very preterm fail to have a ventilatory response to hypoxia beyond the first year of life. |
| Databáze: | OpenAIRE |
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