Fully Integrated Time-Gated 3D Fluorescence Imager for Deep Neural Imaging
| Autor: | Jaebin Choi, Adriaan J. Taal, Sajjad Moazeni, Laurent Moreaux, Kenneth L. Shepard, Eric H. Pollmann, William L. Meng, Michael L. Roukes |
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| Rok vydání: | 2019 |
| Předmět: |
010302 applied physics
0303 health sciences Fluorescence-lifetime imaging microscopy Materials science Avalanche diode Pixel business.industry MicroLED Field of view Iterative reconstruction 01 natural sciences 03 medical and health sciences Optics Single-photon avalanche diode 0103 physical sciences business 030304 developmental biology Diode |
| Zdroj: | BioCAS |
| DOI: | 10.1109/biocas.2019.8919018 |
| Popis: | This paper reports an implantable 3D imager for time-gated fluorescence imaging in the deep brain. Fluorescence excitation is provided by dual ns-pulsed blue micro-light-emitting diodes (µLED), and fluorescence emission is collected by an 8-by64 single-photon avalanche diode (SPAD) array, together packaged to a width of 420 µm to allow deep insertion through a cannula. Each SPAD is masked by a repeating pattern of Talbot gratings that give each pixel a different angular sensitivity, allowing three-dimensional image reconstruction to a resolution of ~20 µm. The integrated imager is able to monitor fluorescent targets across a field of view of 1000 µm by 600 µm by 500 µm at arbitrary tissue depths. |
| Databáze: | OpenAIRE |
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