Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood
| Autor: | Jevan Medlock, Leigh A. Madden, David Allsup, He Liang, Dieter Nees, Vesselin N. Paunov, Anupam A. K. Das |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Hl60 cells
Chemistry Cell Biomedical Engineering 02 engineering and technology General Chemistry General Medicine 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Peripheral blood mononuclear cell Peripheral blood 0104 chemical sciences medicine.anatomical_structure medicine Cancer research General Materials Science Myeloid leukaemia 0210 nano-technology Cell shape |
| Zdroj: | Journal of Materials Chemistry B. 7:3497-3504 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/c9tb00679f |
| Popis: | We report a large scale preparation of bioimprints of layers of cultured human leukemic HL60 cells which can perform cell shape and size recognition from a mixture with peripheral blood mononuclear cells (PBMCs). We demonstrate that the bioimprint-cell attraction combined with surface modification and flow rate control allows depletion of the HL60 cells from peripheral blood which can be used for development of alternative therapies of acute myeloid leukaemia (AML). |
| Databáze: | OpenAIRE |
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