| Autor: |
Gunnar Tufveson, Ragnar Källén, Aksel Foss, C Berne, Torgny Lundgren, Annika Tibell, Bo Nilsson, Marie Felldin, Olle Korsgren, Kaija Salmela |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Transplantation. 79:1289-1293 |
| ISSN: |
0041-1337 |
| DOI: |
10.1097/01.tp.0000157273.60147.7c |
| Popis: |
Islet transplantation is currently being explored as a treatment for patients with type 1 diabetes. At present, the number of patients becoming insulin-independent is rapidly increasing world-wide applying the transplantation protocol originally described by the group in Edmonton. A hallmark in this procedure is repeated infusions of islets obtained from 2 to 4 donors until normoglycemia is achieved. In order to establish islet transplantation as a widely accepted treatment modality, and make tolerance induction regimes applicable, it is essential that the donor:recipient ratio is brought down to 1:1. A conceivable strategy to achieve this goal in clinical islet transplantation is discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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