Vasomotor Impact of Perivascular Adipose Tissue on Coronary Circulation
| Autor: | Marwan M. Merkhan, Hani M Almukhtar, Abdulla A Ahmad |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Vascular smooth muscle Vasomotor Cardiovascular research Public Health Environmental and Occupational Health Adipose tissue medicine.disease Contractility Coronary artery disease Paracrine signalling Coronary circulation medicine.anatomical_structure Internal medicine medicine Cardiology |
| Zdroj: | Indian Journal of Public Health Research & Development. 10:842 |
| ISSN: | 0976-5506 0976-0245 |
| DOI: | 10.5958/0976-5506.2019.02924.3 |
| Popis: | Research during the past decade has highlighted the functional role of perivascular adipose tissue (PVAT) in regulating the contractility of the underlying vascular smooth muscle cell layer. However, the mechanisms underlying these observations are not fully understood. PVAT has a protective role as it could induce vasorelaxation in different anatomical positions. However, there is a considerable evidence that the development and progression of coronary artery disease could be attributed to coronary PVAT. This review provides a comprehensive review of the vasomotor effect of PVAT that identifies the coronary PVAT as a necessary paracrine organ with a significant role in physiology and associated pathologies, and calls for basic cardiovascular research to solve this issue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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